Convenient, once-daily, oral dosing
The recommended dose of WELIREG is 120 mg (three 40-mg tablets) once daily until disease progression or unacceptable toxicity
Not actual size.
WELIREG (belzutifan) should be taken at the same time each day and may be taken with or without food
Advise patients to swallow tablets whole.
Do not chew, crush, or split WELIREG prior to swallowing.
If a dose of WELIREG is missed, it can be taken as soon as possible on the same day.
Resume the regular daily dose schedule for WELIREG the next day. Do not take extra tablets to make up for the missed dose.
If vomiting occurs any time after taking WELIREG, do not retake the dose.
Take the next dose on the next day.
Recommended dose modifications for adverse reactions
First dose reduction:
80 mg orally once daily
Second dose reduction:
40 mg orally once daily
Third dose reduction:
|Adverse reactions||Severitya||Dose modification|
|Anemia||Hemoglobin <9 g/dL or transfusion indicated|
|Life-threatening or urgent intervention indicated|
|Hypoxia||Decreased oxygen saturation with exercise (eg, pulse oximeter <88%)|
|Decreased oxygen saturation at rest (eg, pulse oximeter <88% or PaO2 ≤55 mm Hg) or urgent intervention indicated|
|Life-threatening or recurrent symptomatic hypoxia|
|Other Adverse Reactions||Grade 3|